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Excess Fe 3+ is reduced to Fe 2+ by the metalloreductase STEAP3 and transported into the cytoplasm via ZRT/IRT-like protein 14 (ZIP14) and solute carrier family 11 member 2 (SLC11A2/DMT1), forming the LIP and leading to iron metabolic disorders ( 2 O 2 ) through the Fenton reaction to produce large amounts of hydroxyl radicals